Posters and Presentations

D Wong and W Korz. Tetrodotoxin treatment of mechanical allodynia in rats with oxaliplatin and vincristine-induced neuropathy. American Pain Society 34th annual scientific meeting. May 13-16, 2015. Palm Springs, CA, USA.

J.L.Clifford, M.M. Salas, M McIntyre, D Wong and W.Korz. Tetrodotoxin attenuates thermal hyperalgesia in a rat full thickness thermal injury pain model. American Pain Society 34th annual scientific meeting. May 13-16, 2015. Palm Springs, CA, USA.

N.A. Hagen M.D., L. Cantin R.N., B.Sc., M.B.A., J. Constant, Ph.D., T. Haller, B.Math, M.A., G. Blaise M.D., M. Ong–Lam M.D., P. du Souich M.D., Ph.D., W. Korz, HCA, B. Lapointe M.D. Tetrodotoxin for moderate to severe cancer-related pain: a multicentre, randomized, double-blind, placebo-controlled, parallel-design trial. Canadian Pain Society 36th annual scientific meeting. May 20-23, 2015. Char;pttetown, PEI. Canada

Samuel Goldlust, M.D., Mehran Kavoosi, B.Sc., Walter Korz, HCA, Kenneth Deck, M.D. Tetrodotoxin for chemotherapy induced neuropathic pain. the American Academy of Pain Management 26th Annual Clinical Meeting, September 17-20, 2015 at the Gaylord National Hotel, Washington, DC.

Samuel Goldlust, M.D., Mehran Kavoosi, B.Sc., Walter Korz, HCA, Kenneth Deck, M.D. Tetrodotoxin (TTX) for Chemotherapy Induced Neuropathic Pain (CINP): A Randomized, Double-Blind, Dose-Finding, Placebo Controlled, Multicenter Study. American Academy of Neurology ,68th Annual meeting, April 15-21, 2016 Vancouver, BC, Canada

J.Ruckle1, D. Wong, M. Kavoosi, H Wei, F.Zhao, D. Spanwich, V.Livezev. The Peripheral Action of Tetrodotoxin: A Translational Research Study. IASP 16th World Congress on Pain. Sep 26-30, 2016, Yokohama, Japan.

 

Publications

J. Marcil, J.-S. Walczak, J. Gruindon, et al. Antinociceptive effects of tetrodotoxin (TTX) in rodents. British Journal of Anaesthesia. May 4, 2006

Christian Rosker, Birgit Lohberger, Doris Hofer, et al. The TTX metabolite 4,9-anhydro-TTX in a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am J Physilo cell Physiol 293: C000-C000, 2007. First published May 23, 2007

Hagen NA, Fisher KM, Lapointe B, duSouich P, Chary S, Moulin D, et al. An open-label, multi-dose efficacy and safety study of intramuscular tetrodotoxin in patients with severe cancer-related pain. J Pain Symptom Manage. 2007 Aug 34 (2) 171-182

Antonio Guzman, Antonio R.Fernandez de Henestrosa, Ana-Paz Marin, Anh Ho, et al. Evaluation of the Genotoxic potencial of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo Genotoxicity assays. Mutation Research 634 (2007) 14-24

Neil A.Hagen, Patrick du Souich, Bernard Lapointe, May Ong-Lam, Benoit Dubuc, David Walde, Robin Love, Anh Ho Ngoc. Tetrodotoxin for Moderate to severe Cancer Pain: A Randomized Double Blind, Parallel Design Multicenter Study. J Pain Symptom Manage. 2008 Apr; 35 (4) 420-429

Neil A.Hagen, Bernard Lapointe, May Ong-Lam, Benoit Dubuc, David Walde, B.Gagnon, R. Love, R Goel, P Hawley, Anh Ho Ngoc. Patrick du Souich. Amulticentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Current oncology, Volume 18, Number 3, page e109-e116, 2011

Charles B. berde, Umeshkumar Athiraman, Barak Yahalom,et al. Tetrodocotixin-Bupivacaine-Epinephrine Combinations for prolonged local anesthesia. Marine Drugs, 2011, 9, 2717-2728

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial. Pain Research and Management. Volume 2017, Article ID 7212713, 2017-5-7